CSF Neuroscape Study: Step-by-Step Guide for Participants

Welcome! This guide will help you get started with the UCSF Neuroscape study. Follow each step carefully, and you’ll be ready to participate in our research.

Part 1: Create Your Nexus Account

1. Open your web browser and go to nexus.ucsf.edu
2. Click Get Started
3. Click Create Account
4. Enter your email address, age, first and last name, and choose a password
5. Read and accept the registration statement
6. Go to your email inbox and verify your account
7. Once verified, it will say Registration Complete → click Continue

Part 2: Log In & Explore Your Profile

1. You will return to the home page → click Login
2. Log in using your email and password
3. Click Get Started → you’ll see a short tutorial
4. Click on your name/profile to:

• View or edit your information
• See previous studies
• Enroll in new studies

1. Click Join a Study to enroll in any study you are eligible for
2. Enter a study code if you have one; otherwise, continue without a code
3. Enroll in the Eligibility Study – a 20-minute questionnaire to see which studies you may qualify for
4. Click Neuroscape Studies Open Enrollment to see all currently recruiting studies
5. Check your To-Do List (click Tasks in the top left) – here you will find surveys, activities, and interactive games

Part 3: Eligibility Study

1. Click Join Study → you will return to your dashboard
2. Under Eligibility Study, click Enroll → complete this general eligibility survey

• This survey helps coordinators match you with suitable studies
• Takes 30 minutes to 2 hours
• You may be contacted later for other studies even if none are currently suitable

1. Click Join Eligibility Study
2. Read the Consent Eligibility Screening → click the arrow at the bottom to continue
3. Answer a few questions about the consent form correctly (you have 3 attempts)
4. Start the Eligibility Screening Questionnaire

• About your age, health, lifestyle, and other factors
• Takes ~20 minutes
• If you completed it in the last month, do not repeat it
• No payment for this questionnaire
• Ages 60–85 may be asked to complete cognitive assessments afterward

 Tips for Success

• Make sure your device is charged before starting
• Use a quiet space for tasks requiring focus
• Contact your study coordinator if you run into issues

Nexus Registration Instructions (Older)

Nexus is a mobile study platform developed and used by Neuroscape at the University of California, San Francisco. Neuroscape is a translational neuroscience center at UCSF engaged in technology creation and scientific research on brain function.

Enrolling in a Study (Two Ways)

• Enter a study code (tahda) on the participant landing page
• Or browse current studies on Nexus:
  • Click a study card to view details and enroll

ACE! (45–60 minutes total)

Note: ACE must be played on a desktop or laptop computer.

1. Open the first ACE Explorer task → click the Web link
2. On the ACE login page:
   • Click User account
   • Log in with the same credentials as Nexus
3. Play instructions:
   • Put browser in full-screen mode
   • Select language preference
   • Enter your name as username (if asked)
   • Click Start
4. Complete all ACE modules (~30 minutes)
5. After completing and signing out:
   • Return to Nexus (https://nexus.ucsf.edu) to finish remaining tasks
6. You will be asked to play another set of ACE modules (~additional 30 minutes)

UCSF TAH-DA Samsung Participant Guide

Weekly Tasks

• Keep your watch and tablet charged and powered on.
• Use the tablet to check the Nexus app for new tasks.
• Take weekly watch measurements: ECG, Body Composition, and SpO2.
  • You may take these more often than once per week if you wish.
• Wear the watch during the day and during the night.
• Ensure the watch has at least 50% battery before going to sleep.

Tips

• Set a charging routine and an alarm to remind yourself to take devices off the charger.
• Keep the tablet charging in a location with good connection.

Kit Contents

Devices

• Samsung Galaxy Watch with UCSF – Neuroscape App*
• Samsung Galaxy Tablet with UCSF – Nexus App*
  *Devices may look different than shown.

Accessories

• Watch charging cord and block
• Tablet charging cord and block

Study Tasks and Tips

• Wear the Watch: Every day and night as much as possible throughout the one-year study.
• Weekly Watch Measurements: Once per week measure ECG, Body Composition, and SpO2.
  • Tip: Build this into your routine (same time each week).
  • Tip: Put it on your calendar or use reminder notes.
• Use the Nexus App: Check and complete study tasks.
• Charge Watch & Tablet:
  • Tip: Set an alarm during charging to put it back on.
  • Tip: Charge during a daily routine like cooking dinner or showering.
  • Tip: Keep charger in a frequent location (living room/bedroom).
  • Tip: Avoid keeping charger in a drawer or a low-signal room.
• Water Resistance: Devices are water-resistant, not waterproof (see Water Resistance sections).

Reminders (Changing Reminder Time/Day)

If default reminder time/day doesn’t work, change it on the watch:

1. Open the study app → swipe up → tap Reminders
2. Toggle a reminder type on/off, or tap the reminder to edit (Body composition, SpO2, Sleep, ECG)
3. Use the wheel to pick reminder time
4. Select/unselect days → tap Done
   • For Body Composition: only one day can be selected
   • For daily ECG reminders: select all days

Syncing Study Data

• The watch automatically sends study data while charging.
• If data hasn’t been sent in 3 days, you’ll get an email and a watch reminder.
• Data is synced only while charging (look for the data-syncing icon).
• You’ll continue to receive reminders until data is synced.

Samsung Galaxy Tablet Basics

• Keep tablet turned on and charged.
• Use tablet when Nexus app notifies you.
• Use in a location with good cellular service or Wi-Fi.
• Buttons/ports:
  • Power Button: on/off
  • Volume Button: adjust volume
  • Charging Port: plug in charger

Tablet Charging

1. Plug charging block into an outlet
2. Plug charger into tablet
3. Confirm charging indicator on screen
   • Battery icon indicates charging
   • “100” indicates fully charged
4. Keep tablet charged/powered on in an area with cellular reception

Touch Screen Notes

• Screen protectors/accessories may affect touch functionality
• Gloves, dirty hands, sharp objects, and humid/wet conditions may cause touch issues
• Restart device to clear temporary software problems

Connecting the Tablet to Wi-Fi

1. Tap Settings icon
2. Tap Connections
3. Tap Wi-Fi
4. Select network
5. Enter password (if needed) → tap Connect

Note: For many networks, the name is printed on the router.

Write down your Wi-Fi details:

• Network name: ______________________________
• Network password: __________________________

Watch Overview

• Charge watch daily (~1 hour) or every other day (~2 hours)
• Wear snugly on the left wrist during daily activities and sleep
• Take study measurements weekly by tapping the blue/white heart symbol on the watch face

Activating Your Account (Watch)

1. Tap Activate
2. Wait for activation progress
3. Tap Okay when complete

ECG Spot Check App Troubleshooting

Common issues:

1. Dry skin: moisturize wrist/finger or “fog” finger with breath
2. Excessive motion: stay still; support limbs
3. Poor electrode contact: ensure snug fit; skin not too dry; try moisture
4. Finger removed too soon: keep finger on button for full 30 seconds

Turning the Watch On/Off

Power On: Press and hold both buttons (Home + Back) until it vibrates and “Samsung Galaxy” screen appears.
Power Off: Press and hold both buttons → tap Power off, or open quick panel and tap Power off icon.

Watch Charging

• Plug block into outlet
• Place watch centered on wireless charger
• Watch needs to remain on while charging to transmit data
• Charge before battery drops below 15% (watch won’t collect data below that)

How to Take ECG Spot Checks

1. Sit comfortably, arms supported, feet flat, minimal motion
2. Tap Start on ECG reminder (or open study app → ECG)
3. Rest right finger on top right button (no need to press hard)
4. Stay still for 30 seconds
5. When done, tap Home

Taking Weekly Watch Measurements

Once per week record:

• ECG
• Body Composition
• SpO2

Open study app from watch home screen and choose measurement type.

ECG Notes

• ECG spot check takes 30 seconds
• ECG app does not look for signs of heart attack
• Do not use ECG app if you experience:
  • Shortness of breath
  • Chest tightness or pain
  • Fainting
  • What you think might be a heart attack

Common Watch Questions

How do I avoid skin irritation?

Remove watch if wearing for long periods, sweating, or swimming. If irritation occurs, stop wearing and let skin heal. Contact your doctor if it doesn’t improve, and inform study team.

Can I wear the watch when exercising?

Yes.

Is the watch waterproof?

The watch is water resistant, It is recommended for study purposes that the watch is removed when going in water. However, The watch can't be submerge for 30 minutes in shallow waters.

Watch Water Resistance Tips

• Dry thoroughly with a clean, soft cloth when wet
• Do not expose to high-pressure water
• Avoid salt water; if used, rinse with fresh water and dry
• Impacts/drops may reduce resistance
• Avoid sudden temperature changes and high-velocity activities
• Not intended for scuba diving
• Can stay under 5 feet of water up to 30 minutes

How often should I wear the watch?

Wear as often as possible, including during sleep. Aim for:

• Daytime: 4–5 days per week
• Nighttime: at least 1 night per week
  Place on charger when not wearing.

Should I leave the watch on while charging?

No. Take the watch off to charge it when needed. A helpful tip is to set a reminder on your phone so you do not forget to put the watch back on after charging.

What if the watch won’t turn on?

Battery may be fully drained. Place on charger and wait for charging status to appear; it may take a few minutes. Wait until 5%+ before pressing Home to power on.

What if I’m having problems with the watch?

Restart the watch (off/on). To restart the watch hold down the power button for 7 seconds. If not resolved, contact study team in Nexus app on tablet.

Cleaning the Watch and Band

Wipe sensor area and band with a soft, lint-free cloth. For stubborn grime, lightly dampen cloth with mild soap solution or 70% isopropyl alcohol. Dry thoroughly. Avoid excessive cleaning solution or scrubbing.

How to Wear the Watch (Fit Guide)

Wear on left wrist, comfortably snug.

Incorrect:

• Too loose: two fingers fit between watch and wrist
• Too tight: one finger doesn’t fit

Correct:

• One finger fits between watch and wrist
• Two fingers do not fit
• Watch face lays flat and is not touching wrist bone

UCSF HRPP Research Participant’s Bill of Rights (September 2025)

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — RESEARCH PARTICIPANT’S BILL OF RIGHTS

As an experimental participant you have the following rights:

1. To be told what the study is trying to find out
2. To be told what will happen to you and whether procedures/drugs/devices differ from standard practice
3. To be told about frequent and/or important risks, side effects, or discomforts
4. To be told if you can expect any benefit, and what it might be
5. To be told of other choices you have and how they compare
6. To be allowed to ask questions before and during the study
7. To be told what medical treatment is available if complications arise
8. To refuse participation or change your mind after the study starts, without affecting your care
9. To receive a copy of the signed and dated consent form
10. To be free of pressure when deciding whether to participate

Consent to Participate in a Research Study (TAH-DA Study: 2025.06.17)

Study Time Commitment

Total passive time: 50 weeks

• Wear smartwatch daily and nightly for 50 weeks (biometrics such as heart rate, skin temperature, step count)

Total active time: 37 hours over 50 weeks, across phases:

1. Baseline: 5 hours over 10 weeks
2. Intervention: 18 hours over 12 weeks (30 min, 3 days/week)
3. Waiting Period: 4 hours over 8 weeks
4. Booster: 6 hours over 12 weeks (30 min, 1 day/week)
5. Follow-Up: 4 hours over 8 weeks

All activities are remote.

Risks / Discomforts

Minimal risks. Most common:

• Questionnaires: boredom, discomfort answering questions
• Assessments/training: mental fatigue, boredom
• Smartwatch: some functions can interfere with cardiac implantable electronic devices

Benefits

Information learned may help others in the future.

Participants / Funding / Conflicts

• About 1000 participants
• Funded by Samsung Research America
• No UCSF researcher financial interests

Data Collection & Sharing (Summary)

Data includes identification info, demographics, health, cognitive assessments, and smartwatch biometrics (heart rate, SpO2, PPG, actigraphy, skin temperature, body composition). May be shared with representatives of UC, Samsung Research America, Kajeet, QuantActions, Help Squad, Didit, and other researchers. Samsung/QuantActions/other researchers receive de-identified data; Kajeet needs name/address for shipping; Help Squad provides technical support and can work via anonymized Study ID; Didit performs ID verification via camera comparing face with government ID.

Payment / Devices

• No payment for completing the full study
• If you complete all procedures, you may keep the smartwatch and tablet (as personal property)

Prorated amount to be received by participant if not completing the full study:

• $0 for baseline outcomes + up to five training sessions OR wearing watch <50% of baseline phase
• $50 Amazon e-gift card for 6+ training sessions and watch worn at least 50% but not all tasks complete
• $100 Amazon e-gift card for completing through Waiting Period and watch worn at least 50% but not all tasks complete

If not completing, devices will be locked and must be returned for prorated payment (shipping label provided).

Voluntary Participation

You can stop at any time without penalty. Any data already collected remains in study records. PI may remove you if in your best interest, study rules not followed, or study stopped.

TAH-DA FAQ

TAH-DA FAQ — Study

TAH-DA FAQ — Watch

TAH-DA FAQ — Tablet

TAH-DA FAQ — Nexus

TAH-DA FAQ — Compensation

TAH-DA FAQ — Rhythmicity

TAH-DA FAQ — Coherence

TAH-DA FAQ — MediTrain

TAH-DA FAQ — Labyrinth

TAHDA Task Descriptions (Notes + Tasks)

11/24/25 JG: Started putting these into Nexus; make changes using change tracking or comments to update later.

One page guide link:

• https://neuroscape.ucsf.edu/wp-content/uploads/TAHDA-Study-Phase-by-Phase-Guide.pdf

Consent

Consent Survey

This survey describes the study and asks for your consent. Read carefully and ensure you understand rights and responsibilities. ~5 minutes.

Eligibility

Screening Survey (SSS)

Complete to see if eligible. ~10 minutes.

ID Verification

Verify identity using a valid government ID and a device with a camera. ID and photo are deleted after verification scan.

Baseline

Welcome

Welcome to the TAH-DA study! Total study is ~50 weeks.

Baseline (weeks 1–10):

• ~30 minutes per week (surveys + assessments)
• Weekly tasks open as a set; complete in any order
• No need to wait for previous task to mark complete before doing next
• Recommended: set a weekly time block (flexible timing, but finish each task before taking a break)
• Each baseline week designed to be ≤ 30 minutes

Intervention (weeks 11–22):

• ~2 hours per week
• Includes interventions, wearing Samsung watch, weekly watch measurements, and weekly survey about measurements
• Suggested schedule provided, but flexible
• Goal: train total of 40 days over 90-day intervention phase

Waiting Period (weeks 23–30):

• ~30 minutes per week plus watch wear + weekly measurements (like baseline)

Booster (weeks 31–42):

• ~30 minutes per week
• Includes weekly interventions (30 min), watch wear, weekly measurements, and weekly measurement survey

Follow up (weeks 43–50):

• ~30 minutes per week plus watch wear + weekly measurements

Questions: [email protected]

Note: After completing a task, you can move on even if it says “Processing.” If you’ve finished all tasks for the week, the next task will say “Planned” with the return date.

Baseline Surveys / Tasks (Each includes “Processing” note and “Planned” next-week note)

• Activity Survey (GPAQ) — ~5 minutes
• Health Survey (SF-36) — ~10 minutes
• Sleep Survey (PSQI) — ~10 minutes
• Hearing Survey — ~5 minutes
• Emotion Survey (BAI) — ~10 minutes
• Status Survey (SES) — ~8 minutes
• Cognition Survey (SCD-Q) — ~3 minutes
• Feelings Survey (POMS) — ~5 minutes
• Life Survey (SLS) — ~2 minutes
• Tone Survey (MST) — ~2 minutes
• Thinking Survey (CFQ) — ~10 minutes
• Wellness Survey (PWS) — ~5 minutes
• Mindfulness Survey (MAAS) — ~5 minutes
• Thoughts Survey (NFC) — ~10 minutes
• Illness Survey (IS) — ~2 minutes
• Stress Survey (SSSQ) — ~8 minutes
• Diet Survey (DQQ) — ~5 minutes

ACE Explorer — Web

Browser-based cognitive task with 3 modules (gems). Complete all. ~20 minutes.

After completion: fill out Address Survey to receive participant package (tablet + watch).

Address Survey

Collects mailing address and watch size to ship Samsung tablet and Galaxy watch. If package not received within one week after completion, contact [email protected].

Watch Survey (Recurring)

~3 minutes, taken every week.

Before taking:

• Activate watch and measure ECG, BIA, and SpO2 (see user guide sent in package and available online via “user guide” link reference)

If technical difficulties or package delayed >1 week after Address Survey: contact [email protected].

Reminder: Wear watch as much as possible during the week.

ACE Explorer — Tablet

Tablet-based cognitive task with 5 modules (gems). “4025 minutes” appears in source text.

Instructions:

• Use Samsung tablet
• On tablet: use Start button to open app
• On computer: switch to tablet; open Nexus app and use button to open ACE Explorer, or open ACE Explorer directly

MDT — Part 1

View images and answer questions; complete in one sitting. ~30 minutes.

• Use Samsung tablet
• Press “Start” and select “User Account,” log in with Nexus email/password
• On tablet: use MDT button
• On computer: go to tablet; open via Nexus app button or open MDT directly

Rhythmicity

Assess rhythmic abilities. ~15 minutes.

• Use Samsung tablet
• Use Start button to go directly to app
• Or open via Nexus app or open Rhythmicity directly

MDT — Part 2

Same as MDT Part 1. ~30 minutes.

ORCA

ORCA (Older Adult Research Characterization App) is a 30-minute digital screener on Samsung tablet.

• Press Start
• Select “User Account” and log in with Nexus email/password
• If not on tablet: go to tablet and open via Nexus app button or open ORCA directly

Expectancy Survey

Asks you to judge how much cognitive improvement might be seen after using assigned digital technologies. “105 minutes” appears in source text.

Intervention Phase (Schedule + App Descriptions)

Interventions (Welcome)

You will use three digital technologies, wear the Samsung watch, and take weekly watch measurements over the next 12 weeks.

Goal: complete ~30 sessions on each technology within 12 weeks.
Limit: at most one session per technology per day.

Play 2 Games per day, 3 days a week during the intervention phase. You can pick what order you play the games and what two games you pair together in a day, By the end of the week regardless of the order you plays the games in, You will have played all three games twice in one week.

Suggested schedule (example): two technologies for ~12 minutes each every other day, with alternate days off.

App Task Cards (Intervention)

Coherence

• Rhythm game on Samsung tablet
• ~30 sessions over 12 weeks; ~12 minutes each
• Press Start → select “User Account” → log in with Nexus email/password
• If not on tablet: open in Nexus app or open Coherence directly
• Technical help: [email protected]

Labyrinth

• Wayfinding game on Samsung tablet
• ~30 sessions over 12 weeks; ~12 minutes each
• Same login/launch instructions as above

MediTrain

• Meditation-inspired app on Samsung tablet
• ~30 sessions over 12 weeks; ~12 minutes each
• Same login/launch instructions as above

Watch Survey (During Intervention)

Same recurring Watch Survey instructions; reminder that if late, next survey may open in less than a week.

Booster / Follow-Up

Booster (Welcome + Suggested Schedule)

Goal: complete 8 sessions on each technology within 12 weeks.
Limit: at most one session per technology per day.

Suggested schedule (2 technologies ~12 minutes once a week):

Play two game once per week. These phase are like the intervention phase, but you will only play once a week. You can choose which two games you play, just ensure to rotate between the three games.

Booster Schedule (Weeks 1–12)

• Week 1: MediTrain + Coherence
• Week 2: Labyrinth + MediTrain
• Week 3: Labyrinth + Coherence
• Week 4: MediTrain + Coherence
• Week 5: MediTrain + Labyrinth
• Week 6: Coherence + Labyrinth
• Week 7: Coherence + MediTrain
• Week 8: MediTrain + Labyrinth
• Week 9: Coherence + Labyrinth
• Week 10: Labyrinth + MediTrain
• Week 11: Labyrinth + Coherence
• Week 12: Coherence + MediTrain

(Also included in source: an alternate schedule list with Solitaire/Worder/Sudoku.)

App Task Cards (Booster)

Coherence / Labyrinth / MediTrain

• 8 sessions over 12 weeks; ~12 minutes each
• Press Start → “User Account” → Nexus email/password
• Use tablet; or open via Nexus app; or open app directly

SUDOKU / WORDER/ SOLITAIRE

• 8 sessions over 12 weeks; ~12 minutes each
• Press Start → “User Account” → Nexus email/password
• Use tablet; or open via Nexus app; or open app directly

Additional FAQs

TAH-DA FAQ — ACE EXPLORER WATCH

TAH-DA FAQ — ACE EXPLORER WEB

Please see the link below for the Nexus TAHDA Phase Schedule Table ( This should be added in the answer every time someone is asking for the schedule timeframe): 

Please see the link below for the Watch Size selection Instruction for clients to know which watch size fits them :

Please send the link below if someone ask for a Quick Start guide or for instructions on how to start the Watch and the Tablet : 

Please send the link below if someone ask for the bill of rights :

https://drive.google.com/file/d/1xirop6Zdh-tmk-fSBnwS1z0JH8OTV9v7/view?usp=drive_link

Please send the link below if someone ask for the Calendar of Events : 

https://drive.google.com/file/d/1hTfLdu4MVgyQYK_zJRkGVxsivM5HozIJ/view?usp=sharing

 Documentation Resources : 

ACE Validation
1. General Nexus Registration Instructions:
https://docs.google.com/document/d/1fD0JNMWm8KURzOXWwNCOzT5wlJUX9Yne6SR
cnjXO2hk/edit?usp=sharing
2. Nexus Consent Example (Video): https://drive.google.com/file/d/1Px4MDv9w-
T79hSZgqpfnsC9JtJfp0xta/view?usp=drive_link
3. Logging into ACE with a prefix (video):
https://drive.google.com/file/d/1mBPvNRwS4U0DkbwOoTtM0syZ1x6yXaOa/view?usp=
drive_link
4. Box Link to recruitment material:
https://ucsf.box.com/s/j0nmaphc9dnx8160pkwnbf8k5wq5ok6k
MediTrain
5. Overall app instructions (with some coordinator facing material):
https://docs.google.com/document/d/14JnRDIHRHR13OfAjvw8mriaA7Ha-
W6bqihQC_l_w7OM/edit?usp=sharing

Full UCSF Participant Guide Link Below : 

https://drive.google.com/file/d/1UCQRO7U2QM_C4xOLcG5mIFSBpnhqHpwR/view?usp=sharing

 Coherence Game Tutorial

Hi there!  Welcome to Coherence. Here’s how to play:

 What is Coherence?

Coherence is a rhythm-based brain training game developed by UCSF Neuroscape.
Your goal is to tap in sync with the beat as accurately as possible.

How to Play

1️⃣ Follow the Beat
You’ll see visual cues (like moving shapes or targets) that match a musical rhythm.

2️⃣ Tap in Sync
Tap the screen exactly when the cue reaches the target area.
Try to match the timing of the beat as closely as possible.

3️⃣ Stay Consistent
The more consistently you tap in rhythm, the better your performance score.

4️⃣ Adaptive Challenge
If you're doing well, the rhythm may become faster or more complex.
If you're struggling, the game will adjust to help you improve gradually.

 Tips for Better Performance

•  Use headphones for clearer rhythm cues.
•  Focus on both the sound and the visual timing.
•  Use one steady finger to improve consistency.
•  Stay relaxed — don’t rush your taps.
•  If you miss a beat, refocus on the next one (don’t panic!).

 If You’re Having Trouble

If the game feels too fast or confusing:

• Make sure your device volume is up.
• Try playing in a quiet environment.
• Restart the session if needed.
• If you continue experiencing issues, please contact:📧 [email protected]

Labyrinth Game Tutorial

Hi!  Welcome to Labyrinth — a spatial navigation puzzle game
This game challenges your ability to explore unfamiliar environments and find efficient paths to important locations. It’s designed for research and cognitive training.

 What is Labyrinth?

Labyrinth is a pathfinding puzzle game developed by UCSF Neuroscape. In it, you navigate a virtual environment, learn about landmarks and routes, then use that knowledge to find your way efficiently through the maze.

 How to Play

1️⃣ Start a Session
Launch Labyrinth and begin a new level or environment.

2️⃣ Explore the Maze
Move through the virtual environment to learn where landmarks and pathways are located.

3️⃣ Memorize Your Path
Pay attention to distinctive features and routes so you can recall them later.

4️⃣ Navigate Efficiently
Once you’ve learned the layout, try to find the fastest route between landmarks or to your goal.

5️⃣ Learn & Improve
With each attempt, you’ll get better at remembering layouts and planning efficient routes.

 Tips for Better Navigation

• Observe landmarks carefully — they help you build a mental map.
• Practice repeating routes — this helps reinforce spatial memory.
• Time yourself — challenge yourself to find quicker routes each time.
• Look for patterns — emphasize recognizing similar turns and layouts.

 If You’re Confused

If you’re new to navigation games:

• Take your time learning the environment first.
• Don’t worry if you get lost — the goal is to learn and improve spatial memory.
• Replay earlier levels to master common patterns.

How to play Ace Explorer

Hi!  I’ll guide you through ACE Explorer, developed by UCSF Neuroscape.

Let’s get started.

Step 1: Open the App

Please open ACE Explorer on your device now.

Step 2: Log In (If Required)

If you are part of a study, enter your login details when prompted.

 Make sure your internet connection is stable before continuing.

Tell me when you're logged in.

Step 3: Read the Instructions Carefully

Before each activity, you’ll see instructions or a short tutorial.

 Take your time reading them.
Understanding the rules is very important for good performance.

Ready to begin the first task?

Step 4: Complete the Task

Each activity may ask you to:

• Tap specific targets
• Remember patterns or sequences
• Ignore distractions
• Switch between rules

Focus on doing your best. Some tasks reward accuracy more than speed.

When you finish the first task, tap “Next” and continue.

Step 5: Difficulty May Change

You might notice the task becoming easier or harder.

That’s normal!
ACE Explorer adjusts to your performance automatically.

Just stay focused and keep going.

Step 6: Between Tasks

If you feel tired:

• Take a short break.
• Make sure you're in a quiet space.
• Then continue when you're ready.

Try to complete the session in one sitting if possible.

Step 7: Finishing the Session

Once all tasks are completed, your session will automatically submit.

Great job! Your participation helps support important research.

Worder – How to Play

Hi there!  Welcome to Worder.

Worder is a word-based game that challenges your vocabulary, quick thinking, and attention. It may feel like a simple word puzzle, but it’s designed to help researchers understand language processing and cognitive skills.

 Your Goal

Create or identify correct words based on the letters shown on the screen.

 Step-by-Step Guide

1️⃣ Look at the Letters Carefully
You’ll see a set of letters displayed on your screen.

Take a moment to scan them before making a move.

2️⃣ Form a Word
Use the letters provided to form a valid English word.

Depending on the task, you may:

• Rearrange letters to spell a word
• Identify whether a word is real or not
• Select the correct word from options

Follow the instructions shown at the top of the screen.

4️⃣ Move to the Next Round
After submitting your answer, the game will move you forward automatically.

Difficulty may increase as you continue.

Helpful Tips

• Read the instructions for each round carefully — tasks may change.
• Focus on accuracy first.
• If you get stuck, try rearranging the letters in your mind.
• Stay calm — overthinking can slow you down.

What Worder Measures

Worder helps assess:

• Language processing
• Vocabulary access
• Processing speed
• Attention and decision-making

Solitaire – How to Play

Hi there!  Welcome to Solitaire, developed by UCSF Neuroscape.

This version includes a draw pile and follows classic Solitaire rules, while helping researchers measure attention, planning, and strategy.

Let’s walk through it step by step.

Understanding the Layout

When the game starts, you’ll see three main areas:

1️⃣ Tableau Columns (Main Playing Area)

Location: Center of the screen
These are the large vertical columns of cards laid out across the middle.

• Cards are stacked in columns.
• Some cards may be face down.
• This is where most of your moves happen.

You will arrange cards here in descending order (King → Ace) and alternate colors (red on black, black on red).

2️⃣ Foundation Piles

Location: Top left of the screen

These are four empty slots at the top right.

• Each pile represents one suit (Hearts, Diamonds, Clubs, Spades).
• You must build each pile in ascending order (Ace → King).
• Cards in each foundation must stay in the same suit.

Your goal is to move all cards here.

3️⃣ Draw Pile

Location: Top right of the screen

This is the stack of remaining cards that were not dealt into the tableau.

• Tap the draw pile to reveal a card.
• You can play the revealed card into the tableau or foundation if there’s a legal move.
• If you can’t use it immediately, you may need to draw again.

How to Play

Step 1: Build in the Tableau

• Stack cards in descending order.
• Alternate colors (red card on black card, black on red).
• Only Kings can move into empty columns.

Step 2: Start the Foundations

• Move Aces to the foundation piles when available.
• Build upward by suit (Ace, 2, 3… up to King).

Step 3: Use the Draw Pile Strategically

• Tap the draw pile when you run out of moves.
• Think before placing a drawn card.
• Sometimes it’s better to wait rather than move it immediately.

Step 4: Plan Ahead

Before making a move, ask yourself:

• Will this reveal a hidden card?
• Will this free up a column?
• Could I block future moves?

Planning is key.

Goal of the Game

Move all cards into the four foundation piles, correctly sorted by suit from Ace to King.

Helpful Tips

• Focus on uncovering face-down cards early.
• Freeing a tableau column gives you more flexibility.
• Don’t rush cards into the foundation if you might need them to rearrange the tableau.
• Stay calm and think one or two moves ahead.

Sudoku - How to Play

Hi there! Welcome to Sudoku.

This version of Sudoku is part of a research platform. It follows the classic Sudoku rules while helping researchers understand skills like logical reasoning, attention, and working memory.

Let’s walk through it step by step.

Your Goal

Fill in the grid so that:

• Each row contains the numbers 1–9 with no repeats.
• Each column contains the numbers 1–9 with no repeats.
• Each 3×3 box contains the numbers 1–9 with no repeats.

Every number can appear only once in each row, column, and box.

Step-by-Step Guide

1️⃣ Look at the Starting Numbers

Some numbers are already filled in.
These cannot be changed.

They are your clues.

2️⃣ Pick an Empty Cell

Tap or select an empty square in the grid.

3️⃣ Eliminate Possibilities

Before placing a number, check:

• Does this number already appear in the same row?
• Does it appear in the same column?
• Does it appear in the same 3×3 box?

If yes, you cannot use that number there.

4️⃣ Enter the Correct Number

Once you’re confident, enter the number.

If you’re unsure, take your time — careful thinking is better than guessing.

5️⃣ Continue Filling the Grid

Move systematically:

• Try completing one row or one box at a time.
• Look for rows or boxes that are almost complete.

Keep going until the entire grid is filled correctly.

Helpful Tips

• Start with rows, columns, or boxes that already have many numbers filled in.
• Use the process of elimination — rule out impossible numbers first.
• If stuck, move to another section and come back later.
• Avoid random guessing — logical reasoning works best.

What This Game Measures

This Sudoku task helps assess:

• Logical reasoning
• Attention to detail
• Working memory
• Problem-solving skills

Agent/Customer Service Work Hours

Thank you for contacting us!

Our support hours are 9:00 AM to 5:00 PM PST, Monday through Friday.

UCSF TAH-DA Study Enrollment Guide &
Frequently Asked Questions

Learn more about the study: https://neuroscape.ucsf.edu/tahda-study/
Enrolling in the Study
If You Are New to Nexus (Recommended Method)
1. Open the study enrollment link:
https://nexus.ucsf.edu/register/neuroscape?participant_group=tahda
2. Review the study information and select Join.
3. Create your Nexus account. If you already have a Nexus account, select Log In
instead. Use an email address and password you will remember.
4. Verify your email. Look for an email from 'Nexus Team' titled 'Verify your email.'
Check your Spam/Junk folder if needed. Open the email, select 'Open in Nexus,' then
click 'Complete.'
5. Return to the Nexus website and log in.
6. Select Join Study (during or after the tutorial).
7. Enter the study code: tahda (lowercase only, no spaces or dashes).
Alternative Enrollment Method
1. Go to https://nexus.ucsf.edu
2. Select Get Started, then Create an Account.
3. Enter your account information.
4. Check your email for a message from [email protected].
5. Select Open in Nexus, then Continue.
6. Return to the Nexus homepage and sign in.
7. Select Join Study.
8. Enter the study code: tahda (lowercase only, no spaces or dashes).
If You Already Have a Nexus Account
1. Log in to your Nexus account.
2. Select Join Study.
3. Enter the study code: tahda (lowercase only, no spaces or dashes).
Next Steps: Beginning your Study Participation
After Enrolling
1. If new, complete both the Neuroscape general Consent and Eligibility Surveys.
2. Complete the TAH-DA Consent Survey.
3. Complete the TAH-DA Eligibility Survey.
4. If eligible, complete all assigned surveys by their listed due dates.
5. Additional surveys will become available each week during participation.
Please note: You will not begin using the study smartwatch or tablet immediately. These
devices are introduced a few weeks into participation. Until then, complete study activities
using your personal computer or another internet-connected device.
Frequently Asked Questions
I forgot my password.
1. Select Log In on the Nexus homepage.
2. Select Forgot your password?
3. Follow the instructions sent to your email to reset your password.
I need additional help enrolling.
1. Visit the study enrollment page.
2. Use the HelpBot (blue chat icon in the lower-right corner) for immediate assistance.
3. If the HelpBot cannot resolve your issue, request to speak with a live support agent.
4. If additional assistance is needed, the support team will connect you with the UCSF
TAH-DA Study Coordinator.
Quick Reference
Study Website: https://neuroscape.ucsf.edu/tahda-study/
Nexus : https://nexus.ucsf.edu
Study Code : tahda
Verify Email Sender: Nexus Team

 TAH-DA Study FAQ & HelpBot Knowledge Base
This document is intended for use by the TAH-DA HelpBot. Questions are
organized by topic, with concise, standardized answers.

Contacts & Getting Help
Who should I contact if I need help?
Before contacting the study team, please use the following support pathway:
1. Review this FAQ document.
2. Ask the HelpBot your question.
3. If the HelpBot cannot resolve your issue, request to speak with a live
support agent.
4. If additional assistance is needed, the live agent will connect you with the
UCSF TAH-DA Study Coordinator.
I emailed the TAH-DA study team but have not received a response.
Please first review this FAQ and use the HelpBot, as many common questions can
be answered immediately. If your question cannot be resolved through the
HelpBot or live support, the Study Coordinator will follow up as soon as possible.
Watch Setup & Navigation
How do I navigate my smartwatch?
 The top side button is the power button.
 The bottom side button is the Home button.
 Press the Home button to return to the watch home screen from any app.
 Press the power button, then swipe up from the bottom of the screen to
unlock the watch.
 Tap the screen to open an app.
 Swipe down from the top of the screen to access settings.
 Scroll through apps by dragging upward on the screen.
 Within an app, scroll or swipe left and right to navigate.
How do I activate my watch?
1. Unlock the watch.
2. Open the DHT Health Monitoring app (heart icon with a light blue circle).
3. Select Activate.
Weekly Watch Tasks
What am I required to do with the watch each week?
Once each week:
1. Open the DHT Health Monitoring app on your watch.
2. Complete all four biometric measurements by following the on-screen
instructions.
3. Complete the Weekly Check-In Survey in Nexus.
Important: The biometric measurements and Weekly Check-In Survey are two
separate tasks. Both must be completed every week.
Do I need to transfer my watch data to Nexus?
No. After completing the biometric measurements in the DHT Health Monitoring
app, your data is automatically transmitted to the study team. No additional
syncing is required.
Can I view my health data over time?
Open the Performance tab within the Nexus Tablet app.
If no information appears, you are likely an early participant. This feature is still
being implemented and will become available in a future update.
How often do I need to wear my watch?
To remain enrolled in the study, participants must wear the watch for more than
one full day and one full night each week, on average.
You are welcome to wear it more often, but this is the minimum required level of
participation.
Watch Troubleshooting
My watch isn’t working properly.
Restart the watch:
1. Hold both side buttons for approximately 7 seconds.
2. Select Restart.
3. Wait for the watch to reboot.
If the issue continues after restarting, contact the Study Coordinator.
I receive a “400 Error” when activating my watch.
This usually means the Study Coordinator has not yet completed activation from
the UCSF side.
Please allow up to 2 days after receiving your watch for activation.
If you continue receiving this error 3 days after delivery, contact the Study
Coordinator.
I receive a “No Network Service” error when activating my watch.
Restart the watch using the instructions above.
If the error continues, contact the Study Coordinator.
My watch battery will not charge or drains unusually fast.
Restart the watch using the instructions above.
If the charging issue continues, contact the Study Coordinator.
Nexus App
I am experiencing a general error in the Nexus app.
Try the following steps:
1. Log out of the Nexus app.
2. Log back in.
3. Restart your tablet if the issue continues:
o Hold the power button for approximately 30 seconds.
o Wait 30 seconds.
o Hold the power button again until the Samsung logo appears.
The due dates in my Nexus web account and tablet do not match.
This is a known issue.
Please follow the due dates shown in the Nexus Tablet app.
Tablet
When do I begin using my tablet?
Complete study activities through the Nexus web browser until you reach the
ACE Explorer – Tablet task.
After that point, complete study tasks using the Nexus Tablet app.
My tablet is experiencing an error.
Restart the tablet:
1. Hold the power button for approximately 30 seconds.
2. Wait 30 seconds.
3. Hold the power button again until the Samsung logo appears.
My tablet says “No Tasks Due,” but I believe I have pending tasks.
1. Log into Nexus on a computer or phone.
2. Confirm whether tasks are actually due.
3. If tasks are due:
o Log out of the Nexus Tablet app.
o Log back in.
o Restart the tablet if needed.
If the problem continues, contact the Study Coordinator.
Study Timeline
I have a Weekly Check-In Survey, but I have not received my watch
yet.
Complete the Weekly Check-In Survey.
Select the option indicating that you have not yet received your watch.
I haven’t received my watch or tablet yet. Should I still complete my
surveys?
Yes.
Continue completing all available surveys until your study devices arrive.
Intervention Games
Which games should I play during the intervention phase?
Participants should play three days each week.
On each of those days:
 Play two different games
 Each game lasts approximately 14 minutes
You may choose any two different games each session.
Examples include:
 MediTrain + Labyrinth
 Labyrinth + Coherence
 Coherence + MediTrain
 Worder + Sudoku
 Sudoku + Solitaire
 Solitaire + Worder

TAH-DA FAQ: Bugs/Glitches

The following responses address active glitches/tech bugs as of 7/1. We will want to enter
this information in a location in the Bot we can go back to and remove as we fix these issues.

Coherence and/or Labyrinth restarts from the beginning each training session
Suggested response:
We're aware of this issue and are actively working on a fix. We expect to have it resolved by
the second week of July. In the meantime, please continue using the program as instructed.
This issue will not negatively affect your participation in the study.

Coherence and/or Labyrinth restarts from the beginning each training session
Suggested response:
We're aware of this issue and are actively working on a fix. We expect to have it resolved by
the second week of July. In the meantime, please continue using the program as instructed.
This issue will not negatively affect your participation in the study.

A survey isn't showing as complete
Suggested response:
Please do not complete the survey a second time. If you submitted it once, we can still see
your responses even if Nexus does not display it as completed. Continue with your
scheduled study activities as planned. If you'd like, you can let the HelpBot know about the
issue, but it will not affect your participation.

A survey isn't showing as complete
Suggested response:
Please do not complete the survey a second time. If you submitted it once, we can still see
your responses even if Nexus does not display it as completed. Continue with your
scheduled study activities as planned. If you&#39;d like, you can let the HelpBot know about the
issue, but it will not affect your participation.

My ID Verification task won't mark as complete
Suggested response:
That's okay. We are aware of the issue and are working on a solution. If you&#39;ve already
completed the ID Verification task, there&#39;s no need to repeat it. We can see that your
information was submitted, so you can safely continue with the rest of your scheduled study
tasks.

I'm confused about the Weekly Check-In survey or it keeps appearing
Suggested response:
You only need to complete one Weekly Check-In survey each week. This survey helps
confirm that you've interacted with the DHT Health app on your watch during that week.
Even if the survey continues to appear, you only need to submit it once per week unless
instructed otherwise by the study team.